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Calorie Restriction Science
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Summary
Scientists have found out that eating less makes you live longer. Experiments have been carried out on an organism called baker’s yeast and it was found that by cutting its food supply by about 30-40 % will increase its lifespan by 50-60%. It was found that long living yeasts had life extending mutations in their DNA in a specific family of genes called sirtuins. If the most powerful gene called sir2 was removed from a yeast cell, it died earlier. If extra copies were added, it lived longer. Sirtuins are part of an intricate stress response mechanism since they bring up an organism into action in order to facilitate DNA repair or stop cells from dying. Sirtuins are brought into action by the shortage of food resulting in scientists making the conclusion that having lesser food leads to a longer life. The chemical resveratrol stimulates surtuin genes and allows an organism to live longer. Hence, consumption of red wine is considered advantageous since red wine contains small amounts of resveratrol.
Keywords: baker’s yeast, calorie reduction, DNA, sirtuins, resveratrol
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